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treatment modalities for cancer are surgery, radiation therapy, and systemic therapy (ie, drugs) These medical interventions have been shown to improve survival rates, but they also come with a cost to quality of life and an increased risk for other chronic diseases Surgery is the primary treatment for most solid tumors and often results in a cure all by itself (Frogge & Cunning, 2000) That is, some cancer survivors will not require any additional (ie, adjuvant) therapy after their surgery because their tumors are considered to have been removed entirely by the procedure However, surgery is successful only if the cancer is limited to a small area Like any surgery, there are risks and morbidities depending on the location and extent of the operation (eg, wound-healing complications, infections, loss of function, reduced range of motion, diarrhea, dyspnea, pain, neuropathy, lymphedema, fatigue, anxiety).

When two variables are observed on each occasion, one of the variables (Zi) may be conceptualized as the dependent variable and any additional variables (Xj, Xk, etc.) may be viewed as covariates. A covariate should be related to the dependent variable but be unable to be in uenced by the intervention. This analysis has been labeled a concomitant variable time series analysis (Glass et al., 1975) and is a direct analogue of the analysis of covariance. The covariate is employed to statistically remove some variation from the dependent measure, thus increasing sensitivity. The design matrix and parameter vector are presented in Equation 23.15 for a N1 = N2 = 4 observation example. The rst two parameters estimate the level and change in level, and the last parameter, , estimates the relationship between the covariate and dependent variable. 1 0 X1 1 0 X2 1 0 X3 L 1 0 X4 Xb = (23.15) DL 1 1 X5 1 1 X6 1 1 X7 1 1 X8 Although similar to the analysis of covariance, there are two problems that are unique to multivariate time series analysis. First, the investigator must determine the appropriate lag between the covariate(s) and the dependent variables. This is the same issue as discussed with the cross-lagged correlation above. Second, there may be dependency present in the covariate. It may be necessary to transform the covariate before performing the analysis. One application of this procedure is to control the effects of seasonality in the data (discussed later in this chapter). Time Series Analysis Using Structural Equation Modeling Time series data can be represented as a special case of structural equation modeling (SEM). Although the use of a structural equation modeling program to perform a time series analysis is not recommended, conceptualizing time

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With more than 100 different types of cancer and multiple surgical procedures even for the same cancer (eg, breast, colorectal, lung) it is easy to see that there are potentially dozens of different operations that cancer survivors may face Approximately 60% of cancer survivors will receive radiation therapy at some point during their treatments (Maher, 2000) Radiation therapy can cure some cancers if they are localized, and it can also provide palliative relief if the cancer is causing pain or discomfort External beam radiation therapy is the most common method of delivering radiation It is typically delivered in repeated small doses (ie, fractions) over a 5- to 8-week period to maximize the killing of cancer cells and minimize the damage to normal cells Nevertheless, side effects do occur that are dependent on the dose and site that receives the radiation (Maher, 2000).

A signi cant location is de ned to be a location that is meaningful to the user and to which the user can attach some (meaningful) semantics For example, home , work and airport are signi cant locations whereas SomeStreet 52 , (6042, 4236) or Cell 4287 are not Existing approaches for location clustering can be categorised based on the nature of the used data or based on the type of information that is used to identify the signi cant locations In the following, the rst approach is used In terms of data, the most popular approach has been to use periodically gathered streams of GPS coordinate data In bounded areas such as of ce buildings, campuses, research laboratories or individual cities, background information about the physical location of landmark beacons, such as WiFi access points, may be available.

Radiation therapy can cause acute and late-appearing side effects such as pain, blistering, reduced elasticity, decreased range of motion, nausea, fatigue, dry mouth, diarrhea, lung fibrosis, and cardiomyopathy (Maher, 2000)..

Abelson, R. P. (1979). Social clusters and opinion clusters. In P. W. Holland & S. Leinhardt (Eds.), Perspectives in social network research (pp. 239 256). New York: Academic. Abelson, R. P., Aronson, E., McGuire, W. J., Newcomb, T. M., Rosenberg, M. J., & Tannenbaum, P. H. (Eds.). (1968). Theories of cognitive consistency: A sourcebook. Chicago: RandMcNally. Alexander, C. N., Zucker, L. G., & Brody, C. L. (1970). Experimental expectations and autokinetic experiences: Consistency theories and judgmental convergence. Sociometry, 33, 108 122. Allen, V. L., & Levine, J. M. (1971). Social support and conformity: The role of independent assessment of reality. Journal of Experimental Social Psychology, 4, 48 58. Alloy, L. B., & Abramson, L. Y. (1979). Judgment of contingency in depressed and non-depressed students: Sadder but wiser Journal of Experimental Psychology: General, 108, 441 485. Allport, F. H. (1924). Social psychology. Boston: Riverside Editions/ Houghton Mif in. Allport, G. W. (1939). Personality: A psychological interpretation. New York: Holt.

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